Berkeley lab develops first 3D images of DNA structures

Researchers from the Lawrence Berkeley National Laboratory, managed by the University of California and the U.S. Department of Energy, and the Ohio State University have constructed the first 3D images of DNA structures, according to a press release.

A decade in the making, the researchers have been creating nanoscale materials through a "DNA origami" process. This process allows for a single strand of DNA to be folded into specific shapes, with multiple folded strands ultimately creating a 3D image.

"The research team focused on DNA structures modeled after a basic mechanism called a 'Bennett linkage,' which is a 3D structure consisting of a chain of four rods connected by hinges; this creates a skewed quadrilateral shape in which the hinges are not parallel or in-line," according to the press release. "Using Bennett linkages as building blocks, it's possible to create expandable, useful structures, like supports for tents that can be rapidly assembled."

To capture the 129 3D images, researchers used individual particle electron tomography (IPET) to take pictures of single target molecule from different angles. They then combined those images to create the 3D image. Ultimately, researchers hope to use this method to develop nanoscale molecular devices or makers for medical imaging or research.