Imaging Addiction: Could PET & MR End Cocaine Abuse?

Functional MRI (fMRI) image measuring the strength of connectivity in particular brain circuits before and after subjects were given either a 20-milligram oral dose of methylphenidate used to treat ADHD or a placebo. The scans showed that methylphenidate strengthened connectivity between several brain regions involved in regulating emotions and exerting control over behaviors. Image courtesy of Brookhaven, Stony Brook, and the National Institutes of Health.

Functional MRI (fMRI) image measuring the strength of connectivity in particular brain circuits before and after subjects were given either a 20-milligram oral dose of methylphenidate used to treat ADHD or a placebo. The scans showed that methylphenidate strengthened connectivity between several brain regions involved in regulating emotions and exerting control over behaviors. Image courtesy of Brookhaven, Stony Brook, and the National Institutes of Health.

Cocaine addiction can ruin a person physically and financially, and with an estimated 1.4 million cocaine users in the U.S., thousands will become trapped by their habit. While previous research on the drug and its addictive potential were observational and subjective, imaging is reshaping how we see addiction—and how it will be treated.