Imaging Contrast

Contrast agents are injected into patients to help enhance images to make it easier for radiologists distinguish specific areas of the body from surrounding tissues. The most commonly used agents are iodinated contrast dye for computed tomography (CT), interventional cath lab angiography,  RF fluoroscopy, and in surgical OR procedures. MRI scans typically use gadolinium-based contrast agents. Ultrasound and echocardiography (cardiac ultrasound) imaging use contrast agents composed of microscopic bubbles to enhance images that otherwise would be suboptimal.

Iodine contrast being loaded into a contrast injector in preparation for a cardiac CT scan at Duly Health and Care in Lisle, Illinois. The contrast shortage is causing some healthcare organizations to postpone exams and procedures and ration contrast supplies. Photo by Dave Fornell

Substituting iodinated contrast media in patients with a history of ICM reactions reduces risk by 61%

“For patients with a prior ICM-induced hypersensitivity reaction, healthcare providers must balance the benefit of ICM reuse against the risk of a repeat reaction,” authors of a new meta-analysis published in Radiology said.

July 20, 2022
contrast shortage

Generic, FDA approved contrast agent set to hit the market in wake of nationwide shortage

On July 18 Fresenius Kabi announced that they are rolling out a line of generic contrast media products, starting immediately with Iodixanol Injection USP. 

July 19, 2022
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Contrast shortage update: FDA opens door for U.S. providers to order foreign-labeled Bayer contrast media

Per Bayer’s communications, the contrast agent is manufactured at the same site in Berlin, Germany as the Ultravist that is intended for U.S. markets, but due to its intended distribution abroad it lacks current FDA-approved labeling. 

July 18, 2022
With the shortage, which pertains specifically to all formulations and concentrations of GE Healthcare’s Omnipaque (iohexol), expected to last until mid-June, several organizations have eluded that conservation efforts are of critical importance.#contrastshortage #CTcontrast #iodinatedcontrast

Contrast shortage update: Supplies could continue to lag until September

GE previously indicated that the iodinated contrast shortage would resolve by the end of June.

July 8, 2022

Measures associated with hospital readmission of pancreatitis patients

Beyond readmission, 32.9% of patients with increased pancreatic necrosis volumes required additional invasive interventions.

July 6, 2022
enlarged parathyroid gland

Routine CT scans offer opportunistic assessments of the parathyroid gland

Such assessments could “decrease existing diagnosis gaps,” according to a new study published in Academic Radiology

June 29, 2022
The Society for Cardiovascular Angiography and Interventions (SCAI) has responded to the U.S. Food and Drug Administration’s (FDA’s) recommendation that all infants and young children who receive iodinated contrast media (ICM) undergo thyroid testing. The group pushed back against this proposal, emphasizing that implementation would have “far-reaching consequences.”

Cardiologists push back on FDA’s thyroid monitoring/contrast media proposal

According to a new SCAI statement, the FDA's recommendation would result in "far-reaching consequences" across multiple specialties. 

June 24, 2022
During the 2022 State of the Union address, President Biden outlined a new plan to combat COVID-19 by testing and immediate treatment, plans to reduce drug costs, the need for more mental health coverage, and a call for more cancer research under an NIH program.

Contrast shortage update: House Members urge President Biden to intervene

Members who signed the letter were particularly critical of the fact that the shortage is a result of COVID lockdowns in China, stating that this crisis brings to light “the urgent need to establish an outbound investment review process to ensure that critical capabilities are not being offshored ..."

June 23, 2022

Around the web

Automated AI-generated measurements combined with annotated CT images can improve treatment planning and help referring physicians and patients better understand their disease, explained Sarah Jane Rinehart, MD, director of cardiac imaging with Charleston Area Medical Center.

Two advanced algorithms—one for CAC scores and another for segmenting cardiac chamber volumes—outperformed radiologists when assessing low-dose chest CT scans. 

"Gen AI can help tackle repetitive tasks and provide insights into massive datasets, saving valuable time," Thomas Kurian, CEO of Google Cloud, said Tuesday. 

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